Conformationally restricted amino acids: Diastereoselective substitution at the β-position of L-tryptophan

Article abstract of DOI:10.1016/S0040-4039(00)60945-0

Higher order cuprates add with extreme exo-facial selectivity to the chiral tetrahydropyrroloindole 3, itself prepared in enantiomerically pure form from L-tryptophan: treatment of the adducts with trifluoroacetic acid provides diastereo- and enantiomeric