New Approach to the Synthesis of β-2'-Deoxyribonucleosides: Intramolecular Vorbrueggen Coupling

DOI: 10.1021/jo00056a004

Source and publish data:

Journal of Organic Chemistry p. 807 - 808 (1993)

Update date:2022-08-04

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Authors:

Jung, Michael E.

Castro, Claire

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Article abstract of DOI:10.1021/jo00056a004

Silylation of the O²,5'-linked nucleoside 7 followed by treatment with trimethylsilyl triflate affords the O²,5'-anhydro nucleoside 9 and its hydrolysis product the β-anomer of the 2'-deoxyuridine 10 in good yield in the first example of an oxygen-bridged intramolecular Vorbrueggen coupling.

Full text of DOI:10.1021/jo00056a004

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