New Approach to the Synthesis of β-2'-Deoxyribonucleosides: Intramolecular Vorbrueggen Coupling

Article abstract of DOI:10.1021/jo00056a004

Silylation of the O²,5'-linked nucleoside 7 followed by treatment with trimethylsilyl triflate affords the O²,5'-anhydro nucleoside 9 and its hydrolysis product the β-anomer of the 2'-deoxyuridine 10 in good yield in the first example of an oxygen-bridged intramolecular Vorbrueggen coupling.