Synthesis of enantiomerically pure 6,10-epoxybenzocycloocten-7-amines with CNS-activity

DOI: 10.1002/ardp.19923251110

Source and publish data:

Archiv der Pharmazie p. 733 - 739 (1992)

Update date:2022-07-29

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Authors:

Wunsch Wunsch

Zott Zott

Hofner Hofner

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Article abstract of DOI:10.1002/ardp.19923251110

In an oxa-Pictet-Spengler reaction the methyl (S)-phenyllactate 6 and methyl levulinate (7a) are condensed to the 2-benzopyrans cis-8a and trans-8a, which react with CH₃I to yield the dimethyl ethers cis-9a and trans-9a. Cis-9a and trans-9a can

Full text of DOI:10.1002/ardp.19923251110

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