Homologation of L-phenylalanine to ketomethylene and hydroxyethylene dipeptide isosteres via 2-thiazolyl amino ketone intermediate

Article abstract of DOI:10.1016/S0040-4039(00)60888-2

A highly efficient route is presented for the synthesis of N-protected isosteric dipeptides Pheψ[COCH₂]Gly and Pheψ[CH(OH)CH₂]Phe from L-phenylalanine through 2-thiazolyl α-amino ketone and δ-amino-γ-hydroxy-(E)-α,β-enoate derivative