Study of 5-arylidene-2-thiohydantoins with potential immunomodulating and anticancer activities

Article abstract of DOI:10.1016/0223-5234(92)90140-V

Various 5-arylidene-2-thiohydantoins, N3-substituted and/or S-substituted or not, were synthesized by aldolisation-crotonisation reaction from aromatic aldehydes or cyclic ketones and 2-thiohydantoins. These products, largely original, prepared as potenti