Trisaccharide Sulfate and Its Sulfonamide as an Effective Substrate and Inhibitor of Human Endo- O-sulfatase-1

DOI: 10.1021/jacs.0c00005

Source and publish data:

Journal of the American Chemical Society p. 5282 - 5292 (2020)

Update date:2022-07-29

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Authors:

Cheng, Ting-Jen Rachel

Chiu, Li-Ting

Fan, Chiao-Yuan

Hung, Shang-Cheng

Lin, Wei-Chen

Sabbavarapu, Narayana Murthy

Wong, Chi-Huey

Wu, Chih-Chung

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Article abstract of DOI:10.1021/jacs.0c00005

Human endo-O-sulfatases (Sulf-1 and Sulf-2) are extracellular heparan sulfate proteoglycan (HSPG)-specific 6-O-endosulfatases, which regulate a multitude of cell-signaling events through heparan sulfate (HS)-protein interactions and are associated with th

Full text of DOI:10.1021/jacs.0c00005

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