Conversion of N-Acyl-2,3-dihydro-4-pyridones to 4-Chloro-1,2-dihydropyridines Using the Vilsmeier Reagent. Synthesis of (-)-Coniine and (+/-)-Lupinine

DOI: 10.1021/jo00079a018

Source and publish data:

Journal of Organic Chemistry p. 7732 - 7739 (1993)

Update date:2022-07-31

Topics:

Authors:

Al-awar, Rima S.

Joseph, Sajan P.

Comins, Daniel L.

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Article abstract of DOI:10.1021/jo00079a018

The full details are given of a study on the conversion of dihydropyridones of the type 3 to 4-chloro-1,2-dihydropyridines 4 using a Vilsmeier reagent.The use of 1 equiv of Vilsmeier reagent under mild conditions (ClCHCCl2, rt) transformed several racemic

Full text of DOI:10.1021/jo00079a018

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Product name:N-(4-Bromobutyryl)-2-cyclohexyl-2,3-dihydro-4-pyridone

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