Chemical and Pharmaceutical Bulletin p. 2382 - 2386 (1992)
Update date:2022-08-04
Tatsuoka
Suzuki
Imao
Satoh
Ishihara
Hirotsu
Kihara
Hatta
Horikawa
Sumoto
Miyano
A new series of 4-(1,4-benzoquinon-2-yl)-4-phenylbutanamides (2) were synthesized for evaluation of their pharmacological activities. All these compounds synthesized showed significant antilipidperoxidation (ALP) activities with brain homogenate in rats and some of them possessed a protective effect against hypobaric hypoxia in mice. Especially, a thiomorpholine derivative (21, SUN-4757) showed a wide efficacy spectrum to a variety of experimental screening assays designed for cerebral protective agents, and it had a high LD50 value.
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Doi:10.1016/S0040-4020(01)80502-0
(1993)Doi:10.1016/S0040-4039(00)60087-4
(1993)Doi:10.1016/S0022-328X(00)00247-3
(2000)Doi:10.1007/BF00810931
(1992)Doi:10.1002/adsc.201300414
(2013)Doi:10.1016/S0040-4039(00)61648-9
(1993)