Preparation and pharmacological evaluation of 4-(1,4-benzoquinon-2-yl)-4-phenylbutanamides as potential cerebral protective agents

DOI: 10.1248/cpb.40.2382

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2382 - 2386 (1992)

Update date:2022-08-04

Topics: Pharmacological evaluation Compound Structure

Authors:

Tatsuoka

Suzuki Suzuki

Imao Imao

Satoh Satoh

Ishihara

Hirotsu Hirotsu

Kihara Kihara

Hatta Hatta

Horikawa

Sumoto Sumoto

Miyano Miyano

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Article abstract of DOI:10.1248/cpb.40.2382

A new series of 4-(1,4-benzoquinon-2-yl)-4-phenylbutanamides (2) were synthesized for evaluation of their pharmacological activities. All these compounds synthesized showed significant antilipidperoxidation (ALP) activities with brain homogenate in rats and some of them possessed a protective effect against hypobaric hypoxia in mice. Especially, a thiomorpholine derivative (21, SUN-4757) showed a wide efficacy spectrum to a variety of experimental screening assays designed for cerebral protective agents, and it had a high LD₅₀ value.

Full text of DOI:10.1248/cpb.40.2382

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