Synthesis of potential inhibitors of hemagglutination by influenza virus: Chemoenzymic preparation of N-5 analogs of N-acetylneuraminic acid

DOI: 10.1016/S0040-4020(01)80502-0

Source and publish data:

Tetrahedron p. 1 - 12 (1993)

Update date:2022-08-04

Topics: Biological testing Purification and characterization Structure-Activity Relationship (SAR) Studies Scale-up and Production Enzymatic Reaction Conditions

Authors:

Sparks, Michelle A.

Williams, Kevin W.

Lukacs, Christine

Schrell, Andreas

Priebe, Gregory

Spaltenstein, Andreas

Whitesides, George M.

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Article abstract of DOI:10.1016/S0040-4020(01)80502-0

A chemoenzymic route to neuraminic acid 2 is described. This method is based on conversion of N-carbobenzoxymannosamine (ManCBz) 3 to N-carbobenzoxyneuraminic acid (Neu5CBz) 4, catalyzed by Neu5Ac aldolase. The Neu5CBz 4 was converted to the α-methyl glyc

Full text of DOI:10.1016/S0040-4020(01)80502-0

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