Synthesis of a hybrid molecule containing neocarzinostatin chromophore analogue and minor groove binder

DOI: 10.1016/S0040-4039(00)61648-9

Source and publish data:

Tetrahedron Letters p. 669 - 672 (1993)

Update date:2022-08-04

Topics: Characterization Optimization Biological testing Purification Scale-up Design and Planning Functional Group Protection

Authors:

Tokuda Tokuda

Fujiwara

Gomibuchi

Hirama Hirama

Uesugi Uesugi

Sugiura Sugiura

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Article abstract of DOI:10.1016/S0040-4039(00)61648-9

A designed hybrid (1) of neocarzinostatin chromophore model and netropsin-type minor groove binder was synthesized and its improved ability of DNA cleavage has been demonstrated.

Full text of DOI:10.1016/S0040-4039(00)61648-9

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