Synthesis of inositol phospholipids with thiophosphoester bonds

Article abstract of DOI:10.1016/0040-4039(93)88048-N

The synthesis of phosphatidylinositol (PI) analogues (±)1-O-(1-O-octadecanoyl-2-O-acetyl-rac-3-thioglycerylphosphoryl)-myo -inositol(7), (±)1-O-(1,2-di-O-octadecyl-rac-3-thioglycerylphosphoryl)-myo-inositol (14a), (±)1-O-(1,2-di-O-octyl-rac-3-thioglycerylphosphoryl)-myo-inositol(14b ) and (±)1-O-(1-O-octadecyl-2-O-methyl-rac-3-thioglycerylphosphoryl)-myo-in ositol(14c) designed to show a novel mode of PI-phospholipase C (PI-PLC) inhibition, is described.