Bioorganic and Medicinal Chemistry Letters p. 929 - 932 (1997)
Update date:2022-09-26
Topics:
Wu, Yusheng
Zhao, Xu-Yang
De Clercq
Vandewalle
Bouillon
Verstuyf
The synthesis of both 1α-hydroxy-25 (R and S)-25,26-epoxy-23-yne vitamin D3 and of both 1α,25(R and S),26-trihydroxy-23-yne vitamin D3 is described. Biological evaluation includes the study of calcemic effect, receptor binding and cell differentiation.
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