Stereoselective one-pot method for the introduction of an amino group to a cyclohexane ring. Preparation of the octahydroisobenzofuro[7a,1-d]oxazole ring system

Article abstract of DOI:10.1055/s-1992-26353

Stereoselective one-pot synthesis of octahydroisobenzofuro[7a,1-d]oxazole-2,5-diones 7-14 via base-catalyzed addition-cyclization reaction of hydroxy lactones 4a-4d with various isocyanates 5a-5f is described. The ring system contains diastereoselectively