Asymmetric synthesis of (S)-4,5-difluoro-2-methylindoline

Article abstract of DOI:10.1080/00397919408010615

(S)-4,5-difluoro-2-methylindoline (S)-11 was synthesized effectively by asymmetric reduction of N-[(R)-N-p-tolysulfonyl]prolinyl-2-(2-oxo)propyl-3,4-difluoroanilide 4b followed by successive methylsulfonylation and intramolecular cyclization.

Full text of DOI:10.1080/00397919408010615

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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Asymmetric Synthesis
of (S)-4,5-Difluoro-2-
Methylindoline
Koichi Tsuji a & Hiroshi Ishikawa a
a Microbiological Research Institute, Otsuka
Pharmaceutical Co. Ltd , Kagasuno 463-10,
Kawauchi-cho, Tokushima, 771-01
Published online: 23 Sep 2006.
To cite this article: Koichi Tsuji & Hiroshi Ishikawa (1994) Asymmetric Synthesis of
(S)-4,5-Difluoro-2-Methylindoline, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 24:20, 2943-2953, DOI:
10.1080/00397919408010615
To link to this article: http://dx.doi.org/10.1080/00397919408010615
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