Archiv der Pharmazie p. 791 - 796 (1992)
Update date:2022-09-26
Topics:
Dannhardt
Kiermaier
Mayer
Roelcke
The M+. of 4-Benzyl-1,2,3,4-2-methyl-tetrahydroisoquinoline (1) decomposes by competing loss of H.- or H3C.-radicals, of H3C-NH2, C6H6 and C7H8, respectively, or by RDA-fission. The fragmentation mechanisms are studied on the specifically deuterated analogues 2-8. The elimination of C6H6 and C7H8 is preceded by extensive H/D-exchange, especially between the positions 1, 4, the benzylic methylene group, and the aromatic positions (pos. 5, 8, and phenyl).
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Doi:10.1055/s-0033-1339346
(2013)Doi:10.1002/cmdc.201700271
(2017)Doi:10.1248/cpb.38.562
(1990)Doi:10.1016/S0960-894X(00)00463-7
(2000)Doi:10.1016/j.tetlet.2007.11.192
(2008)Doi:10.1016/S0040-4020(01)90157-7
(1993)