Synthesis and thromboxane A2 antagonistic activity activity of indane derivatives.

DOI: 10.1016/S0960-894X(99)00014-1

Source and publish data:

Bioorganic and medicinal chemistry letters p. 401 - 406 (1999)

Update date:2022-07-30

Topics:

Authors:

Shinozaki

Sato Sato

Iwakuma Iwakuma

Sato Sato

Kurimoto

Yoshida Yoshida

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Article abstract of DOI:10.1016/S0960-894X(99)00014-1

A new series of indane derivatives were prepared and evaluated for their thromboxane A2 (TXA2, 1) antagonistic activity. Among these compounds, 24a (Z-335) was found to be a potent TXA2 antagonist in oral administration.

Full text of DOI:10.1016/S0960-894X(99)00014-1

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