Construction of a Key Intermediate in the Asymmetric Synthesis of Chiral Taxanes

DOI: 10.1039/c39930000151

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 151 - 152 (1993)

Update date:2022-07-31

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Authors:

Boa, Andrew, N.

Clark, Jonathan

Jenkins, Paul R.

Lawrence, Nicholas J.

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Article abstract of DOI:10.1039/c39930000151

The radical bromination of acetal 5 followed by zinc-promoted fragmentation gives the highly functionalised, homochiral cyclohexane 7, which possesses the carbon skeleton of the C-ring of taxol; nucleophilic addition of dimethyllithium cuprate to 8 follow

Full text of DOI:10.1039/c39930000151

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