Tetrahedron Letters p. 381 - 384 (1993)
Update date:2022-08-04
Topics:
Magaard, Victoria W.
Sanchez, Robert M.
Bean, John W.
Moore, Michael L.
A convenient synthesis of Boc-DL-5,5-dimethylproline methyl ester is described.This conformationally-constrained amino acid may be expected to exist predominantly in the cis peptide bond isomer when incorporated into peptides.The peptide bond in the model peptide Boc-Phe-Me2Pro-OMe is shown to be 90percent in the cis isomer. Keywords: 5,5-dimethylproline; synthesis; cis peptide bond; conformational constraint; cis-trans isomerism.
View MoreContact:0086-22-23410962
Address:17-201, Ningfuli, Shuishanggongyuandong road,Nankai district, Tianjin, China
Jiangsu King Road New Materials Co., Ltd.
website:http://www.jskingroad.com
Contact:0519-85720726 0519-85720721 13584535752
Address:No.1,Weihua Road,Xinbei District,Changzhou City,Jiangsu Province
Cerametek Materials（ShenZhen）Co., Ltd.
Contact:+86-755-2324.2554
Address:A3-#9, YongChuan Street, Suite 501
Angelisun(Chongqing) Pharmaceutical Co., LTD.
Contact:+86-23-68030926-816
Address:D1-7 Tech & Entrepreneurs Park, Kecheng Road, Erlang Hi-Tech Areas, Chongqing, China
BrightGene Bio-Medical Technology Co., Ltd.
website:https://en.bright-gene.com/
Contact:+86-512-62551801
Address:Building C25 - C31, No. 218 Xinghu Road, Suzhou Industrial Park, Suzhou, Jiangsu, China.
Doi:10.1021/ja808673n
(2008)Doi:10.1021/jm00116a003
(1991)Doi:10.1016/S0022-1139(00)00405-X
(2001)Doi:10.1021/jm9504969
(1996)Doi:10.1021/jo9607673
(1996)Doi:10.1021/j100119a048
(1993)
