Synthesis of 2- and 6-fluoro analogues of threo-3-(3,4-dihydroxyphenyl)serine (2- and 6-fluoro-threo-DOPS)

Article abstract of DOI:10.1016/0022-1139(95)98347-6

2-Fluoro- and 6-fluoro-threo-dihydroxyphenylserine (2-F- and 6-F-threo-DOPS) have the potential, after crossing the blood-brain barrier, of functioning in the central nervous system as biological precursors of 2- and 6-fluoronorepinephrine (2- and 6-F-NE)