Stereoselective synthesis of 4,5-dihydroxy-D-erythro- and 4,5-dihydroxy-D-threo-L-norvaline from D-ribonolactone

Article abstract of DOI:10.1016/S0040-4020(01)85821-X

Nitrogen functions have been introduced stereoselectively at the C-2 position in D-ribonolactone derivatives in order to prepared the title unnatural amino acids. The synthetic strategies lie in the inversion of configuration in S(N)2-type substitution re