Journal of Medicinal Chemistry p. 1041 - 1047 (1993)
Update date:2022-07-29
Topics:
Lampe
Chou
Hanna
Di Meo
Erhardt
Hagedorn III
Ingebretsen
Cantor
Seven 3-alkyl-4-aryl-1,5-dihydro-2H-pyrrol-2-ones were prepared as potential inhibitors of cardiac cAMP phosphodiesterase (PDE). The design of these compounds made use of rolipram, a known inhibitor of the brain cAMP PDE isozyme, as a lead structure and w
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