Enantiocontrolled construction of bicyclic proline derivatives via one-pot generation and intramolecular trapping of chiral stabilised azomethine ylids

DOI: 10.1016/0040-4039(93)85121-C

Source and publish data:

Tetrahedron Letters p. 537 - 540 (1993)

Update date:2022-08-03

Topics:

Authors:

Harwood Harwood

Lilley Lilley

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Article abstract of DOI:10.1016/0040-4039(93)85121-C

Aldehydes possessing unsaturation at C-5 or C-6 condense with nylmorpholin-2-one (1), generating chiral stabilised azomethine ylids which undergo concommitant diastereospecific intramolecular 3+2 dipolar cycloaddition to furnish adducts (2), (4), and (5)

Full text of DOI:10.1016/0040-4039(93)85121-C

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