Dibenzoxepin derivatives: Thromboxane A2 synthase inhibition and thromboxane A2 receptor antagonism combined in one molecule

DOI: 10.1021/jm00063a011

Source and publish data:

Journal of Medicinal Chemistry p. 1613 - 1618 (1993)

Update date:2022-08-03

Topics:

Authors:

Ohshima Ohshima

Sato Sato

Obase Obase

Miki Miki

Ishii Ishii

Kawakage

Shirakura

Karasawa

Kubo Kubo

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Article abstract of DOI:10.1021/jm00063a011

A new series of 6,11-dihydrodibenz[b,e]oxepin derivatives exerting both thromboxane synthase inhibitory (TXS-I) and thromboxane receptor antagonist (TXRA) activities is described. (-)-11-[(3-Pyridylmethyl)thio]-6,11- dihydrodibenz[b,e]oxepin-2-carboxylic

Full text of DOI:10.1021/jm00063a011

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