Tetrahedron p. 1901 - 1912 (1993)
Update date:2022-09-26
Topics: Chiral Synthetic studies Novel Synthesis
Nakatani
Arai
Terashima
Novel synthesis of the chiral 10-membered dienediynes (2 and 3) related to neocarzinostatin chromophore was accomplished by utilizing cyclization of an epoxy acetylene as a key step. The epoxy acetylene was prepared from the (Z)-dienediyne diol which could be obtained by coupling reaction of the (Z)-enol triflates (5) with the optically active acetylene diol (25) derived from D-xylose.
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