Synthesis p. 121 - 125 (1993)
Update date:2022-08-04
Topics:
Verardo
Giumanini
Strazzolini
Poiana
Primary aromatic amines 1 with a variety of ring substituents are easily converted to their N-monoalkyl derivatives 3 by a simple variation of the sodium borohydride/sulfuric acid/carbonyl compound procedure previously described for their N-permethylations. The procedure is suitable for the α-minodeuterium labelling of the new N-substituent.
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Doi:10.1016/S0022-1139(00)80105-0
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(1993)Doi:10.1055/s-1999-2712
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(2007)
