Reductive N-monoalkylation of primary aromatic amines

Article abstract of DOI:10.1055/s-1993-25813

Primary aromatic amines 1 with a variety of ring substituents are easily converted to their N-monoalkyl derivatives 3 by a simple variation of the sodium borohydride/sulfuric acid/carbonyl compound procedure previously described for their N-permethylations. The procedure is suitable for the α-minodeuterium labelling of the new N-substituent.