Journal of Medicinal Chemistry p. 8931 - 8942 (2013)
Update date:2022-07-30
Topics: In vitro Testing High-Throughput Screening In Vivo Testing Lead Compound Identification Cell-Based Assays Target Selection Chemical Optimization
Liu, Feng
Barsyte-Lovejoy, Dalia
Li, Fengling
Xiong, Yan
Korboukh, Victoria
Huang, Xi-Ping
Allali-Hassani, Abdellah
Janzen, William P.
Roth, Bryan L.
Frye, Stephen V.
Arrowsmith, Cheryl H.
Brown, Peter J.
Vedadi, Masoud
Jin, Jian
Among epigenetic "writers", "readers", and "erasers", the lysine methyltransferases G9a and GLP, which catalyze mono- and dimethylation of histone H3 lysine 9 (H3K9me2) and nonhistone proteins, have been implicated in a variety of human diseases. A "toolk
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