Regiospecific addition of Grignard reagents to the 4-position of activated imidazo[4,5-c]pyridine. A convenient method for the synthesis of 4-alkyl(ary

DOI: 10.1016/S0040-4039(00)91954-3

Source and publish data:

Tetrahedron Letters p. 1885 - 1888 (1993)

Update date:2022-08-03

Topics:

Authors:

Khanna, Ish K.

Weier, Richard M.

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Article abstract of DOI:10.1016/S0040-4039(00)91954-3

The addition of Grignard reagents to 5-acylimidazopyridinium salts gives 4-substituted 5-acyl-4,5-dihydroimidazopyridines. This reaction was utilized.

Full text of DOI:10.1016/S0040-4039(00)91954-3

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Product name:4-Phenyl-1-(2-trimethylsilanyl-ethoxymethyl)-1,4-dihydro-imidazo[4,5-c]pyridine-5-carboxylic acid phenyl ester

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