Synthesis from D-lyxonolactone of 1,4-dideoxy-1,4-imino-L-arabinitol, a glucosidase inhibitor with in vitro anti-viral activity

DOI: 10.1016/S0040-4020(01)90163-2

Source and publish data:

Tetrahedron p. 3359 - 3366 (1993)

Update date:2022-09-26

Topics:

Authors:

Behling, James R.

Campbell, Arthur L.

Babiak, Kevin A.

Ng, John S.

Medic, John

Farid, Payman

Fleet, George W. J.

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Article abstract of DOI:10.1016/S0040-4020(01)90163-2

Benzylidenation is the only protection required in a 7 step synthesis of the hydrochloride of 1,4-dideoxy-1,4-imino-L-arabinitol from D-lxyonolactone in an overall yield of 21%.

Full text of DOI:10.1016/S0040-4020(01)90163-2

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Product name:3,5(S)-O-benzylidene-2-O-methanesulphonyl-D-lyxono-1,4-lactone

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