Lactones. 24. "Gamma-lactonized" neuroleptics--synthesis, stereochemistry and affinity at the D2 receptor

DOI: 10.1002/ardp.19933260508

Source and publish data:

Archiv der Pharmazie p. 291 - 296 (1993)

Update date:2022-07-30

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Authors:

Lehmann Lehmann

Schulze Schulze

Radwansky

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Article abstract of DOI:10.1002/ardp.19933260508

Addition of piperidines 15a-d to methylene lactones 8,14a gives the "gamma-lactonized" diphenylbutylpiperidine-type neuroleptics 3a,b,d,4a-d. 8 can be produced by cyclization or--as well as 14--from the corresponding alpha-carboxylactone. 1H- and 13C-nmr

Full text of DOI:10.1002/ardp.19933260508

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