European Journal of Medicinal Chemistry p. 687 - 697 (1991)
Update date:2022-07-30
Topics:
Jentzer
Vanelle
Crozet
Maldonado
Barreau
New 5-nitroimidazoles bearing a trisubstituted ethylenic double bond in position 2 were prepared by reacting various 1-alkyl-2-chloromethyl-5-nitroimidazole with 3-nitrolactam anions by S(RN)1 mechanism in phase-transfer catalysis conditions. These compounds showed in vitro and in vivo antianaerobic activity which was clearly greater than that of metronidazole. Structure-activity relationships have been discussed.
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