Carbon based nucleophilic ring opening of activated monocyclic β-lactams; synthesis and stereochemical assignment of the ACE inhibitor WF-10129

DOI: 10.1016/0040-4020(95)00157-4

Source and publish data:

Tetrahedron p. 4733 - 4762 (1995)

Update date:2022-09-26

Topics:

Authors:

Baldwin, Jack E.

Adlington, Robert M.

Russell, Andrew T.

Smith, Marie L.

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Article abstract of DOI:10.1016/0040-4020(95)00157-4

The preparation of γ-keto α-amino acids via carbon based nucleophilic ring opening of activated monocyclic β-lactams was examined and applied to the synthesis and stereochemical assignment of the dipeptide angiotensin convering enzyme (ACE) inhibitor, WF-

Full text of DOI:10.1016/0040-4020(95)00157-4

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