New Strategy in the Synthesis of 3-Deoxy-D-manno-2-octulosonic acid (KDO), 2-Deoxy-KDO and Thioglycoside of KDO

Article abstract of DOI:10.1016/S0040-4020(01)81292-8

To take advantage of the synthetic intermediates on the way to KDO, we developed a new strategy based on an aqueous hetero Diels-Alder reaction with a water-soluble diene derived from D-glyceraldehyde, followed by a dihydroxylation of the newly created do