A novel constrained reduced-amide inhibitor of HIV-1 protease derived from the sequential incorporation of γ-turn mimetics into a model substrate

DOI: 10.1021/jm00068a008

Source and publish data:

Journal of Medicinal Chemistry p. 2321 - 2331 (1993)

Update date:2022-07-30

Topics:

Authors:

Newlander

Callahan

Moore Moore

Tomaszek Jr.

Huffman Huffman

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Article abstract of DOI:10.1021/jm00068a008

C₇ mimetics, designed to lock three amino acid residues of a peptide chain into a γ-turn conformation, were introduced sequentially between the P₃ to P₂' positions of a model HIV-1 protease substrate I (resulting in compou

Full text of DOI:10.1021/jm00068a008

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