A novel constrained reduced-amide inhibitor of HIV-1 protease derived from the sequential incorporation of γ-turn mimetics into a model substrate

DOI: 10.1021/jm00068a008

Source and publish data:

Journal of Medicinal Chemistry p. 2321 - 2331 (1993)

Update date:2022-07-30

Topics:

Authors:

Newlander

Callahan

Moore Moore

Tomaszek Jr.

Huffman Huffman

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00068a008

C₇ mimetics, designed to lock three amino acid residues of a peptide chain into a γ-turn conformation, were introduced sequentially between the P₃ to P₂' positions of a model HIV-1 protease substrate I (resulting in compou

Full text of DOI:10.1021/jm00068a008

Products guided by the article

Product name:1-<1(S)-(tert-butoxycarbonyl)-2-methylpropyl>-5-<2-<(tert-butyldiphenylsilyl)oxy>ethyl>-2,3,6,7-tetrahydro-1H-azepin-2-one

Cas No:150494-36-3

R&D Labs maybe for 150494-36-3

Wuhan Sunrise Pharmaceutical Technology Co., Ltd

Contact:+86-27-83314682

Address:Room 340, New material Industrial base No.17, Gu Tian Five Lu , Qiaokou District, Wuhan , China
HANGZHOU TOYOND BIOTECH CO., LTD

Contact:+86-571-86965177

Address:No. 189, Fengqi East Road, Hangzhou, China
Chinapeptides Co,. Ltd

Contact:+86-021-50792271

Address:Building 24A, 300 Chuantu Road, Chuansha, Pudong new area, Shanghai, China, 201202
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Contact:+86-21-5161 3915

Address:Shanghai YangPu
HEBEI BRANT PHARMACEUTICAL

Contact:+86-0311-84455288-844

Address:Mayu Industrial Park, Jinzhou, Hebei, China.

Relevant to this article

Cytotoxic and anti-HIV-1 constituents of Gardenia obtusifolia and their modified compounds

Doi:10.1016/S0040-4020(02)00999-7
(2002)
Synthesis of a series of 4-(arylethynyl)-6-chloro-4-cyclopropyl-3,4- dihydroquinazolin-2(1H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

Doi:10.1021/jm00041a023
(1994)
Synthesis of sterically congested acetic acid derivatives: The reaction of hindered α-oxo esters with pentasubstituted aryl Grignard reagents

Doi:10.1055/s-1993-25911
(1993)
N-LITHIO-N-(2-LITHIOETHYL)- AND N-LITHIO-N-(3-LITHIOPROPYL)-BENZAMIDE: DIRECT PREPARATION AND SYNTHETIC APPLICATIONS OF 2-LITHIOETHYL- AND 3-LITHIOPROPYL-AMINE EQUIVALENTS

Doi:10.1016/S0040-4020(01)80078-8
(1989)
Allylsilanes in organic synthesis; an approach to the stereoselective synthesis of units for natural product synthesis

Doi:10.1016/S0040-4039(00)94430-7
(1990)
New accelerated strategy for the synthesis of poly(ether ketone) dendrons

Doi:10.1021/jo015805j
(2002)

Article Doi