Intramolecular 11-(3,4) ene approach to the bicyclic core of enediyne antibiotics: Dynemicin, calicheamicin, and esperamicin

DOI: 10.1016/S0040-4039(00)73638-0

Source and publish data:

Tetrahedron Letters p. 3571 - 3572 (1993)

Update date:2022-08-03

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Authors:

Mikami, Koichi

Matsueda, Hiroyuki

Nakai, Takeshi

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Article abstract of DOI:10.1016/S0040-4039(00)73638-0

The first example of 11-(3,4) ene cyclization is shown to afford a bicyclic subunit of antitumor agents such as dynemicin and calicheamicin/esperamicin.

Full text of DOI:10.1016/S0040-4039(00)73638-0

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