7-Deazaguanosine: Synthesis of an Oligoribonucleotide Building Block and Disaggregation of the U-G-G-G-G-U G4 Structure by the Modified Base

Article abstract of DOI:10.1002/hlca.19930760404

Building blocks derived from 7-deazaguanosine (c⁷G, 1) were prepared for solid-phase oligoribonucleotide synthesis.Compound 1 was converted into the isobutyryl derivative 2b and the (dimethylamino)methylidene compound 3 (Scheme 1).After trityla