NMR Studies on Conformational and N-Configurational Interconversion in 3-Methyl Derivatives of the Non-Narcotic Analgesic Drug Nefopam

Article abstract of DOI:10.1002/mrc.1260310911

Two different N-configurations and two different eight-membered ring conformations were found in the diastereomeric crystalline (1R,3S)/(1S,3R)- and (1R,3R)/(1S,3S)-3 -methylnefopam hydrochloride salts. (1)H and (13)C NMR spectroscopy showed that both cry