Synthesis and evaluation of unsymmetrically substituted polyamine analogues as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential antitumor agents

DOI: 10.1021/jm00072a020

Source and publish data:

Journal of Medicinal Chemistry p. 2998 - 3004 (1993)

Update date:2022-08-03

Topics:

Authors:

Saab Saab

West West

Bieszk Bieszk

Preuss Preuss

Mank Mank

Casero Jr.

Woster Woster

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Article abstract of DOI:10.1021/jm00072a020

Spermidine/spermine-N¹-acetyltranferase (SSAT), the rate-limiting step in polyamine catabolism, is critical for the interconversion and modulation of cellular polyamines. Inhibitor-initiated induction of this enzyme also appears to correlate wi

Full text of DOI:10.1021/jm00072a020

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