A convenient synthesis of tricyclic gamma-lactams, stimulating B-C-D rings of azasteroids via Michael addition reaction

Article abstract of DOI:10.1080/00397919308009853

Cinnamoylchloride on treatment with arylaminomalonates produced the γ-lactam diester derivatives. Highly stereoselective hydrolysis of the diester, produced the trans acid, which on homologation by Arndt-Eistert's method followed by PPA cyclization generated the tricyclic γ-lactam derivatives simulating B-C-D ring of many azasteroids in good overall yield.

Full text of DOI:10.1080/00397919308009853

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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A Convenient Synthesis of
Tricyclic Gamma-Lactams,
Simulating B-C-D Rings of
Azasteroids Via Michael
Addition Reaction
Gandhi K. Kar a , Basanta G. Chatterjee a & Jayanta
K. Ray a
a Department of Chemistry , Indian Institute of
Technology , Kharagpur, 721302, India
Published online: 16 Feb 2007.
To cite this article: Gandhi K. Kar , Basanta G. Chatterjee & Jayanta K. Ray
(1993) A Convenient Synthesis of Tricyclic Gamma-Lactams, Simulating B-C-D
Rings of Azasteroids Via Michael Addition Reaction, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 23:14,
1953-1958, DOI: 10.1080/00397919308009853
To link to this article: http://dx.doi.org/10.1080/00397919308009853
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