Synthesis of Acyclic Polyol Derivatives via Enzyme-Mediated Aldol Reaction

DOI: 10.1016/S0040-4039(00)74050-0

Source and publish data:

Tetrahedron Letters p. 4935 - 4938 (1993)

Update date:2022-07-29

Topics:

Authors:

Matsumoto, Kazutsugu

Shimagaki, Masayuki

Nakata, Tadashi

Oishi, Takeshi

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Article abstract of DOI:10.1016/S0040-4039(00)74050-0

Enzyme-mediated stereoselective aldol reaction between dihydroxyacetone phosphate (DHAP, 1) and (2R,4R)-6-benzyloxy-2,4-dimethoxyhexanal (8) was catalyzed by rabbit muscle aldolase (RAMA) to generate (3S,4R,5R,7R)-trihydroxyketone 12, which could be easily transformed to the masked polyhydroxylated compound 15 corresponding to the C-9-C-16 segment of pentamycin (6).

Full text of DOI:10.1016/S0040-4039(00)74050-0

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Product name:(2R,4R)-6-benzyloxy-2,4-dimethoxyhexanal

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