A highly efficient route to taxotere by the β-lactam synthon method

Article abstract of DOI:10.1016/S0040-4039(00)60514-2

Taxotere, a highly promising anticancer drug, is synthesized through an efficient coupling of 7,10-diTroc-10-deacetylbaccatin III with enantiomerically pure (3R,4S)-1-^tBOC-3-EEO- 4-phenylazetidin-2-one which is obtained via chiral ester enolate - imine cyclocondensation.