A highly efficient route to taxotere by the β-lactam synthon method

DOI: 10.1016/S0040-4039(00)60514-2

Source and publish data:

Tetrahedron Letters p. 4149 - 4152 (1993)

Update date:2022-08-04

Topics:

Authors:

Ojima, Iwao

Sun, Chung Ming

Zucco, Martine

Park, Young Boon

Duclos, Olivier

Kuduk, Scott

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Article abstract of DOI:10.1016/S0040-4039(00)60514-2

Taxotere, a highly promising anticancer drug, is synthesized through an efficient coupling of 7,10-diTroc-10-deacetylbaccatin III with enantiomerically pure (3R,4S)-1-^tBOC-3-EEO- 4-phenylazetidin-2-one which is obtained via chiral ester enolate - imine cyclocondensation.

Full text of DOI:10.1016/S0040-4039(00)60514-2

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Product name:1-Azetidinecarboxylic acid, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-oxo-4-phenyl-, 1,1-dimethylethyl ester, (3R,4S)-

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