Enantioselective synthesis of 2-alkyl-2-cyanocycloalkanones with a quaternary stereogenic center

DOI: 10.1055/s-1993-25929

Source and publish data:

Synthesis p. 725 - 728 (1993)

Update date:2022-07-29

Topics:

Authors:

Enders Enders

Zamponi Zamponi

Raabe Raabe

Runsink Runsink

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Article abstract of DOI:10.1055/s-1993-25929

2-Alkyl-2-cyanocycloalkanones 4 bearing a quaternary stereogenic center are synthesized in good overall yields and high enantiomeric excesses (ee = 90-95%) employing the SAMP-/RAMP-hydrazone method. The absolute configuration is confirmed by NMR-spectroscopic investigations on SAMP-hydrazone 3a and an X-ray structure analysis of SAMP-hydrazone 3f.

Full text of DOI:10.1055/s-1993-25929

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