Enantioselective synthesis of 2-alkyl-2-cyanocycloalkanones with a quaternary stereogenic center

DOI: 10.1055/s-1993-25929

Source and publish data:

Synthesis p. 725 - 728 (1993)

Update date:2022-07-29

Topics:

Authors:

Enders Enders

Zamponi Zamponi

Raabe Raabe

Runsink Runsink

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1055/s-1993-25929

2-Alkyl-2-cyanocycloalkanones 4 bearing a quaternary stereogenic center are synthesized in good overall yields and high enantiomeric excesses (ee = 90-95%) employing the SAMP-/RAMP-hydrazone method. The absolute configuration is confirmed by NMR-spectroscopic investigations on SAMP-hydrazone 3a and an X-ray structure analysis of SAMP-hydrazone 3f.

Full text of DOI:10.1055/s-1993-25929

Products guided by the article

Product name:(S)-2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-1-propyl-cyclooctanecarbonitrile

Cas No:152297-30-8

R&D Labs maybe for 152297-30-8

Jiangsu Zhenfang Chemical CO.,LTD.(Suzhou Zhenfang Chemical Factory)

Contact:+86-512-69598882

Address:Room1201, Jiayuan Road No.1018, Xiangcheng District, Suzhou, China
Shenyang Xinyihan Chemical Technology Co., Ltd.

Contact:+86-18525026267

Address:362, aigongbeijei street 23 , tiexi district,Shenyang, Liaoning, China
Taizhou YOJOY Chemical Co., Ltd.

Contact:13857143241

Address:Yangfu Industrial Park, Xianju, Zhejiang, P. R. China
Ring Specialty Chemicals Inc.

website:http://www.ringchemicals.com/

Contact:+1-416-493-6870

Address:Toronto, Canada
Shanghai Longschem Co.,Ltd

Contact:021-36356756

Address:Room601,Building No.14,280 Yangcheng Road,Shanghai

Relevant to this article

First total synthesis of mueggelone

Doi:10.1016/S0040-4039(00)01285-5
(2000)
Synthesis and anti-influenza virus activity of tricyclic compounds with a unique amine moiety

Doi:10.1248/cpb.49.379
(2001)
Palladium(II) and Copper(I) Cocatalyzed Coupling of Stereodefined Alkenyl(phenyl)iodonium Triflates and Unsaturated Tri-n-butylstannanes

Doi:10.1021/ja00077a083
(1993)
Doi:10.1021/ja01614a033
(1955)
Regioselective preparation of diethyl 3,4-disubstituted 1,5-dihydro-5-oxo-2H-pyrrol-2-ylphosphonates and their coupling with aldehydes. Application to the synthesis of C/D-rings component of phycocyanobilin

Doi:10.1246/bcsj.67.3320
(1994)
Infrared spectroscopy and ab initio computation in conformer determination of keto ester and diketo triphenylphosphonium ylides

Doi:10.1016/j.molstruc.2009.07.028
(2009)

Article Doi