Simple method for controlling stereoselection in Mannich cyclization reactions of aldehydes

DOI: 10.1021/jo00077a004

Source and publish data:

Journal of Organic Chemistry p. 6947 - 6948 (1993)

Update date:2022-07-30

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Authors:

Heerding

Hong Hong

Kado Kado

Look Look

Overman Overman

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Article abstract of DOI:10.1021/jo00077a004

By judicious choice of the nitrogen substituent, either stereoisomer of 1-substituted 1,2,3,4,6,7,8,8a-octahydroisoquinolines can be prepared by reactions of allylsilane amines 3 with aldehydes.

Full text of DOI:10.1021/jo00077a004

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