Synthesis and biochemical studies of 7α-substituted androsta-1,4-diene- 3,17-diones as enzyme-activated irreversible inhibitors of aromatase

Article abstract of DOI:10.1016/0039-128X(93)90081-W

Several 7α-thiosubstituted derivatives of androstenedione have demonstrated effective inhibition of aromatase, the cytochrome P450 enzyme complex responsible for the biosynthesis of estrogens. Introduction of an additional double bond in the A ring result