New synthesis of 2′, 3′-dideoxy-2′, 3′-didehydro-3′-C-substituted thymidines

Article abstract of DOI:10.1016/S0040-4020(01)80201-5

The Michael addition reaction of phenylthiolate anion with 2′,3′-dideoxy-2′,3′-didehydro-2′-nitrothymidine 1 and subsequent Henry reaction at C-3′ with various electron deficient reagents as formaldehyde, methylvinyl ketone and acrylonitrile has produced