Synthetic studies on diterpenoid quinones with interleukin-1 inhibitory activity. Total synthesis of (±)- and (+)-triptoquinone A

Article abstract of DOI:10.1021/jo00081a021

An efficient first total synthesis of (±)- and (+)-triptoquinone A (1), a novel diterpenoid quinone with significant inhibitory activity against interleukin-1 releases, has been completed. Birch reduction of tricyclic enone (±)-7, prepared from known 6-me