Potent Gastrin-Releasing Peptide (GRP) Antagonists Derived from GRP (19-27) with a C-Terminal DProΨPhe-NH2 and N-Terminal Aromatic Residues

Article abstract of DOI:10.1021/jm00030a002

We have previously reported that octapeptides with a -DProΨPhe-NH2 C-terminus are potent GRP antagonists and have greatly enhanced in vivo stability.Now we report the detailed syntheses of such peptides and additional attempts to further increase m