Journal of Organic Chemistry p. 7652 - 7659 (1993)
Update date:2022-08-04
Topics:
Ghosh, Arun
Miller, Marvin J.
The synthesis of analogs of arthrobactin (5), a microbial iron chelator, and its imide 8 are described.The differentially protected citric acid residue 31 served as the key intermediate in making conjugates having a generalized structure 14 with two representative carbacephalosporin units, 15 and 16.Both conjugates, 49 and 51, showed antibiotic activity, while conjugate 51 obtained from β-lactam 16 bearing a phenylglycyl side chain was shown to be more effective.
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Doi:10.1016/S0040-4039(00)60696-2
(1993)Doi:10.1002/jhet.5570300402
(1993)Doi:10.1016/S0040-4039(00)73820-2
(1993)Doi:10.1080/00397919308013797
(1993)Doi:10.1002/anie.201805479
(2018)Doi:10.1021/acs.joc.8b00792
(2018)
