Synthesis and biological activity of a fluoroketonucleoside: 7-(3-deoxy-3-fluoro-β-D-glycero-hex-2-enopyranosyl-4-ulose)theophylline

Article abstract of DOI:10.1016/S0008-6215(00)90551-2

The title compound 5 was synthesized by direct oxidation of the fluoro precursor and not from an epoxyketo intermediate according to the Paulsen procedure, which has been used until now to obtain bromo- and chloro-ketonucleosides.Antineoplastic activity a