Synthesis of Naltrexone-Derived δ-Opioid Antagonists. Role of Conformation of the δ Address Moiety

DOI: 10.1021/jm00031a006

Source and publish data:

Journal of Medicinal Chemistry p. 579 - 585 (1994)

Update date:2022-08-03

Topics:

Authors:

Portoghese, P. S.

Sultana, M.

Moe, S. T.

Takemori, A. E.

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Article abstract of DOI:10.1021/jm00031a006

Naltrindole (1) (NTI) is a highly potent and selective δ-opioid receptor antagonist.In an effort to understand the origin of the high potency, affinity, and selectivity of NTI, we have examined the conformational role of its indolic benzene moiety through

Full text of DOI:10.1021/jm00031a006

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