Synthesis of Naltrexone-Derived δ-Opioid Antagonists. Role of Conformation of the δ Address Moiety

Article abstract of DOI:10.1021/jm00031a006

Naltrindole (1) (NTI) is a highly potent and selective δ-opioid receptor antagonist.In an effort to understand the origin of the high potency, affinity, and selectivity of NTI, we have examined the conformational role of its indolic benzene moiety through