A stereoselective total synthesis of (±)-erythrodiene

Article abstract of DOI:10.1016/S0040-4039(00)61502-2

Erythrodiene, a unique spirobicyclic sesquiterpene hydrocarbon from the Caribbean gorgonian coral Erythropodium caribaeorum, has been synthesized from 4-isopropylcyclohexanol in 8-steps and approximately 16% overall yield. The synthesis features a stereoselective intramolecular carbomercuration reaction as the key step.